Luis Suarez dented Manchester City's hopes of reaching the Champions League quarter-finals with two goals as Barcelona secured a last-16 first-leg victory at Etihad Stadium.
The former Liverpool striker drove home a rebound before stabbing in a second as Barcelona dominated the first half.
Sergio Aguero's powerful finish after the break gave City hope.
The hosts were reduced to 10-men when Gael Clichy was sent off before Lionel Messi had a late penalty saved.
The result means Manuel Pellegrini's side will need to score at least twice in the second leg at the Nou Camp on 18 March to have a chance of reaching the last eight.
Luis Suarez (nine goals, 12 assists) has been involved in 21 goals in his first 23 Barcelona games
Luis Suarez has netted four goals in his last two games against Joe Hart
Sergio Aguero has scored 11 goals in his last 10 Champions League games
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